H2N2V1, Main, Exploration, bibRecord, 002D82

[The effect of amplifying reproduction of influenza virus in mouse lungs during simultaneous infection with two cold-adapted strains].

Identifieur interne : 002D82 ( Main/Exploration ); précédent : 002D81; suivant : 002D83

[The effect of amplifying reproduction of influenza virus in mouse lungs during simultaneous infection with two cold-adapted strains].

Auteurs : Iu R. Romanov ; A Iu Egorov ; K V Lisovskaia ; T E Medvedeva ; G N Nevedomskaia ; G I Aleksandrova ; A I Klimov

Source :

Voprosy virusologii [ 0507-4088 ]

RBID : pubmed:2609639

Descripteurs français

KwdFr :
- Adaptation biologique, Animaux, Basse température, Infections à Orthomyxoviridae (microbiologie), Poumon (microbiologie), Réplication virale, Souris, Virus de la grippe A (pathogénicité), Virus de la grippe A (physiologie).
MESH :
- microbiologie : Infections à Orthomyxoviridae, Poumon.
- pathogénicité : Virus de la grippe A.
- physiologie : Virus de la grippe A.
- Adaptation biologique, Animaux, Basse température, Réplication virale, Souris.

English descriptors

KwdEn :
- Adaptation, Biological, Animals, Cold Temperature, Influenza A virus (pathogenicity), Influenza A virus (physiology), Lung (microbiology), Mice, Orthomyxoviridae Infections (microbiology), Virus Replication.
MESH :
- microbiology : Lung, Orthomyxoviridae Infections.
- pathogenicity : Influenza A virus.
- physiology : Influenza A virus.
- Adaptation, Biological, Animals, Cold Temperature, Mice, Virus Replication.

Abstract

Reproduction of cold-adapted (ca) strains of influenza virus in the lungs of white mice after separate and combined inoculation and the properties of isolates derived from the infected animals were studied. It was shown that after combined inoculation with ca and ts strains A/Leningrad/134/17/57 (H2N2) and A/PR/8/59/1 (H1N1) ca recombinants could develop loosing some ts mutations and possessing (unlike the master strains) pneumo-virulence for mice. All the pneumo-virulent reassortants inherited hemagglutinin from the ca A/PR/8/59/1 strain and PB1 protein from the ca A/Leningrad/134/17/57 strain. The results indicate that it is unsafe to construct live recombinant divaccines by combining the recombinants produced from different donors of attenuation.

PubMed: 2609639

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Reproduction of cold-adapted (ca) strains of influenza virus in the lungs of white mice after separate and combined inoculation and the properties of isolates derived from the infected animals were studied. It was shown that after combined inoculation with ca and ts strains A/Leningrad/134/17/57 (H2N2) and A/PR/8/59/1 (H1N1) ca recombinants could develop loosing some ts mutations and possessing (unlike the master strains) pneumo-virulence for mice. All the pneumo-virulent reassortants inherited hemagglutinin from the ca A/PR/8/59/1 strain and PB1 protein from the ca A/Leningrad/134/17/57 strain. The results indicate that it is unsafe to construct live recombinant divaccines by combining the recombinants produced from different donors of attenuation.</div>
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[The effect of amplifying reproduction of influenza virus in mouse lungs during simultaneous infection with two cold-adapted strains].

[The effect of amplifying reproduction of influenza virus in mouse lungs during simultaneous infection with two cold-adapted strains].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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